RAPID COMMUNICATION Sustained, Retransplantable, Multilineage Engraftment of Highly Purified Adult Human Bone Marrow Stem Cells In Vivo
نویسندگان
چکیده
Data from many laboratory and clinical investigations indicate that CD34+ cells comprise approximately 1% of human bone marrow (BM) mononuclear cells, including the progenitor cells of all the lymphohematopoietic lineages and lymphohematopoietic stem cells (stem cells). Because stem cells are an important but rare cell type in the CD34+ cell population, investigators have subdivided the CD34+ cell population to further enrich stem cells. The CD34+/CD38cell subset comprises less than 10% of human CD34+ adult BM cells (equivalent t o <0.1% of marrow mononuclear cells), lacks lineage (/in) antigens, contains cells with in vitro replating capacity, and is predicted to be highly enriched for stem cells. The present investigation tested whether the CD34+/CD38subset of adult human marrow generates human hematopoiesis after transfer t o preimmune fetal sheep. CD34+/ CD38cells purified from marrow using immunomagnetic
منابع مشابه
Sustained, retransplantable, multilineage engraftment of highly purified adult human bone marrow stem cells in vivo.
Data from many laboratory and clinical investigations indicate that CD34+ cells comprise approximately 1% of human bone marrow (BM) mononuclear cells, including the progenitor cells of all the lymphohematopoietic lineages and lymphohematopoietic stem cells (stem cells). Because stem cells are an important but rare cell type in the CD34+ cell population, investigators have subdivided the CD34+ c...
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